| 17. Round | 05/02/2022 | Lyon-La Duchère | - | Hyères FC | 1:1 | ||||
| 20. Round | 05/03/2022 | Lyon-La Duchère | - | FC Martigues | 2:2 |  |
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| 22. Round | 19/03/2022 | Lyon-La Duchère | - | AS Saint-Priest | 2:3 | ||||
| 23. Round | 26/03/2022 | Étoile FC | - | Lyon-La Duchère | 3:1 | ||||
| 24. Round | 09/04/2022 | Lyon-La Duchère | - | GOAL FC | 1:0 | ||||
| 25. Round | 16/04/2022 | Aubagne FC | - | Lyon-La Duchère | 1:1 | ||||
| 26. Round | 23/04/2022 | Lyon-La Duchère | - | Jura Sud | 1:4 | ||||
| 27. Round | 30/04/2022 | Olympique Marseille B | - | Lyon-La Duchère | 2:1 | |
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| 28. Round | 14/05/2022 | Lyon-La Duchère | - | Marignane Gignac FC | 3:1 | ||||
| 29. Round | 21/05/2022 | Olympique Lyonnais B | - | Lyon-La Duchère | 0:4 |
France
Guadeloupe