| 1. Round | 28/07/2021 | Venados FC | - | Club Celaya | 1:2 | ||||
| 2. Round | 03/08/2021 | Club Celaya | - | TM Fútbol Club | 0:0 | ||||
| 4. Round | 18/08/2021 | Club Celaya | - | Coyotes de Tlaxcala | 3:0 | ||||
| 5. Round | 26/08/2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Round | 02/09/2021 | Club Celaya | - | Pumas Tabasco | 1:2 |  |
|||
| 7. Round | 09/09/2021 | Tepatitlán | - | Club Celaya | 0:1 | |
|||
| 11. Round | 06/10/2021 | Club Celaya | - | Cimarrones de Sonora | 1:0 |  |
|||
| 12. Round | 14/10/2021 | Leones Negros | - | Club Celaya | 1:2 | |
|||
| 13. Round | 20/10/2021 | Club Celaya | - | Alebrijes de Oaxaca | 1:0 | ||||
| 14. Round | 27/10/2021 | Mineros de Zacatecas | - | Club Celaya | 3:1 | ||||
| 15. Round | 03/11/2021 | Club Celaya | - | Dorados de Sinaloa | 2:2 | ||||
| 17. Round | 17/11/2021 | Club Celaya | - | Cancún FC | 3:1 |
Argentina
Spain