| 1. Round | 13/09/2000 | FK Krivbas (old) | - | FC Nantes | 0:1 | ||||
| 1. Round | 27/09/2000 | FC Nantes | - | FK Krivbas (old) | 5:0 | ||||
| 2. Round | 25/10/2000 | FC Nantes | - | MTK Hungaria | 2:1 | ||||
| 2. Round | 08/11/2000 | MTK Hungaria | - | FC Nantes | 0:1 | ||||
| 3. Round | 22/11/2000 | FC Nantes | - | Lausanne Sports | 4:3 | ||||
| 3. Round | 06/12/2000 | Lausanne Sports | - | FC Nantes | 1:3 | ||||
| Round of 16 | 14/02/2001 | FC Porto | - | FC Nantes | 3:1 | ||||
| Round of 16 | 21/02/2001 | FC Nantes | - | FC Porto | 2:1 |  |
France
