1. Round | 28/08/2021 | PEC Zwolle [U21] | - | De Graafschap [U21] | 2:1 | ||||
4. Round | 25/09/2021 | De Graafschap [U21] | - | FC Emmen [U21] | 1:1 | ||||
5. Round | 02/10/2021 | Vitesse [U21] | - | De Graafschap [U21] | 1:1 | ||||
6. Round | 16/10/2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
8. Round | 30/10/2021 | De Graafschap [U21] | - | Vitesse [U21] | 6:0 | ||||
13. Round | 12/02/2022 | Alphense Boys [U21] | - | De Graafschap [U21] | 1:3 |