| 4. Round | 01/08/2021 | River Plate | - | Huracán | 1:1 | ||||
| 5. Round | 08/08/2021 | Godoy Cruz | - | River Plate | 2:1 |  |
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| 6. Round | 14/08/2021 | River Plate | - | Vélez Sarsfield | 2:0 | |
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| 7. Round | 23/08/2021 | Gimnasia de La Plata | - | River Plate | 1:1 | |
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| 8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | ||||
| 9. Round | 30/08/2021 | Sarmiento de Junín | - | River Plate | 1:2 | ||||
| 10. Round | 06/09/2021 | River Plate | - | Independiente | 1:1 | ||||
| 13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 15. Round | 09/10/2021 | Banfield | - | River Plate | 0:1 | ||||
| 16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Round | 22/10/2021 | Talleres de Córdoba | - | River Plate | 0:2 | |
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| 18. Round | 25/10/2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 19. Round | 31/10/2021 | Estudiantes | - | River Plate | 1:1 | ||||
| 20. Round | 07/11/2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
| 21. Round | 22/11/2021 | Platense | - | River Plate | 0:1 | |
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| 23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 |
Argentina