| 1. Round | 11/01/2021 | CF América [Women] | - | Atlas Guadalajara [Women] | 1:2 | ||||
| 2. Round | 18/01/2021 | CF América [Women] | - | FC Juárez [Women] | 2:1 | ||||
| 3. Round | 24/01/2021 | Mazatlán FC [Women] | - | CF América [Women] | 1:1 |  |
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| 4. Round | 01/02/2021 | CF América [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
| 5. Round | 04/02/2021 | Club Necaxa [Women] | - | CF América [Women] | 0:1 | ||||
| 6. Round | 07/02/2021 | CF América [Women] | - | Club León [Women] | 1:1 | ||||
| 7. Round | 12/02/2021 | Gallos Blancos [Women] | - | CF América [Women] | 1:2 | ||||
| 8. Round | 25/02/2021 | CF América [Women] | - | Pumas UNAM [Women] | 3:1 | ||||
| 9. Round | 07/03/2021 | Atlético San Luis [Women] | - | CF América [Women] | 1:0 | ||||
| 10. Round | 12/03/2021 | CF América [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 11. Round | 16/03/2021 | CF América [Women] | - | UANL Tigres [Women] | 2:2 | |
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| 12. Round | 23/03/2021 | CF Pachuca [Women] | - | CF América [Women] | 0:0 | ||||
| 15. Round | 19/04/2021 | CF Monterrey [Women] | - | CF América [Women] | 1:1 | ||||
| 16. Round | 25/04/2021 | CF América [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 17. Round | 02/05/2021 | Puebla FC [Women] | - | CF América [Women] | 1:0 |
Mexico