| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 | ||||
| 3. Round | 21/08/2021 | Louhans-Cuiseaux | - | AS Monaco B | 1:1 | ||||
| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 7. Round | 18/09/2021 | AS Monaco B | - | FC Martigues | 2:0 | ||||
| 8. Round | 25/09/2021 | GFA Rumilly Vallières | - | AS Monaco B | 1:2 | ||||
| 9. Round | 09/10/2021 | AS Monaco B | - | AS Saint-Priest | 4:2 | ||||
| 15. Round | 15/01/2022 | AS Monaco B | - | Marignane Gignac FC | 0:1 | ||||
| 18. Round | 12/02/2022 | Hyères FC | - | AS Monaco B | 3:1 | ||||
| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 |  |
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| 20. Round | 05/03/2022 | AS Monaco B | - | SC Toulon | 0:1 | ||||
| 21. Round | 12/03/2022 | FC Martigues | - | AS Monaco B | 1:2 | ||||
| 22. Round | 19/03/2022 | AS Monaco B | - | GFA Rumilly Vallières | 2:2 | ||||
| 23. Round | 26/03/2022 | AS Saint-Priest | - | AS Monaco B | 2:1 | ||||
| 24. Round | 09/04/2022 | AS Monaco B | - | Étoile FC | 0:1 | ||||
| 25. Round | 16/04/2022 | GOAL FC | - | AS Monaco B | 5:0 | ||||
| 26. Round | 23/04/2022 | AS Monaco B | - | Aubagne FC | 1:1 | ||||
| 27. Round | 30/04/2022 | Jura Sud | - | AS Monaco B | 5:0 | ||||
| 30. Round | 28/05/2022 | AS Monaco B | - | Olympique Lyonnais B | 4:1 |
France