| 1. Round | 04/06/2022 | Platense | - | Godoy Cruz | 2:1 | ||||
| 2. Round | 12/06/2022 | Godoy Cruz | - | Racing Club | 2:0 | ||||
| 3. Round | 16/06/2022 | Rosario Central | - | Godoy Cruz | 1:0 |  |
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| 6. Round | 02/07/2022 | Godoy Cruz | - | Colón de Santa Fe | 1:0 | ||||
| 7. Round | 11/07/2022 | River Plate | - | Godoy Cruz | 0:2 |  |
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| 8. Round | 17/07/2022 | Godoy Cruz | - | Lanús | 2:1 | ||||
| 9. Round | 21/07/2022 | Huracán | - | Godoy Cruz | 0:0 | ||||
| 10. Round | 26/07/2022 | Unión de Santa Fe | - | Godoy Cruz | 2:1 | ||||
| 16. Round | 27/08/2022 | Newell's Old Boys | - | Godoy Cruz | 1:2 | ||||
| 17. Round | 05/09/2022 | Godoy Cruz | - | Arsenal de Sarandí | 1:0 | ||||
| 18. Round | 10/09/2022 | Central Córdoba SdE | - | Godoy Cruz | 3:0 | |
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| 21. Round | 23/09/2022 | Godoy Cruz | - | Boca Juniors | 0:1 | ||||
| 22. Round | 01/10/2022 | Banfield | - | Godoy Cruz | 1:1 | ||||
| 23. Round | 04/10/2022 | Godoy Cruz | - | San Lorenzo | 0:0 | ||||
| 24. Round | 09/10/2022 | Talleres de Córdoba | - | Godoy Cruz | 3:1 |
Argentina