| 1. Round | 04/06/2022 | San Lorenzo | - | Independiente | 1:1 | ||||
| 3. Round | 14/06/2022 | San Lorenzo | - | Arsenal de Sarandí | 3:3 | ||||
| 4. Round | 22/06/2022 | Central Córdoba SdE | - | San Lorenzo | 0:2 | ||||
| 5. Round | 26/06/2022 | San Lorenzo | - | Tigre | 1:1 | ||||
| 6. Round | 03/07/2022 | Barracas Central | - | San Lorenzo | 2:1 | ||||
| 7. Round | 09/07/2022 | San Lorenzo | - | Boca Juniors | 2:1 |  |
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| 8. Round | 17/07/2022 | Banfield | - | San Lorenzo | 1:1 | ||||
| 9. Round | 20/07/2022 | San Lorenzo | - | Unión de Santa Fe | 2:2 | ||||
| 11. Round | 30/07/2022 | Argentinos Juniors | - | San Lorenzo | 0:1 | ||||
| 12. Round | 07/08/2022 | San Lorenzo | - | Estudiantes | 0:0 | ||||
| 13. Round | 13/08/2022 | Patronato de Paraná | - | San Lorenzo | 3:2 | ||||
| 14. Round | 16/08/2022 | San Lorenzo | - | Platense | 2:0 | ||||
| 15. Round | 22/08/2022 | Racing Club | - | San Lorenzo | 1:2 | ||||
| 16. Round | 27/08/2022 | San Lorenzo | - | Rosario Central | 1:1 |
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