| 1. Round | 07/08/2021 | Louhans-Cuiseaux | - | Hyères FC | 2:0 | ||||
| 2. Round | 14/08/2021 | SC Toulon | - | Hyères FC | 1:1 | ||||
| 3. Round | 21/08/2021 | Hyères FC | - | Lyon-La Duchère | 0:0 | ||||
| 4. Round | 28/08/2021 | AS Monaco B | - | Hyères FC | 0:1 |  |
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| 6. Round | 11/09/2021 | GFA Rumilly Vallières | - | Hyères FC | 2:1 | |
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| 7. Round | 18/09/2021 | Hyères FC | - | AS Saint-Priest | 1:0 | ||||
| 8. Round | 25/09/2021 | Étoile FC | - | Hyères FC | 0:0 | ||||
| 9. Round | 09/10/2021 | Hyères FC | - | GOAL FC | 1:1 | ||||
| 15. Round | 29/01/2022 | Hyères FC | - | RC Grasse | 1:1 | |
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| 17. Round | 05/02/2022 | Lyon-La Duchère | - | Hyères FC | 1:1 | ||||
| 19. Round | 19/02/2022 | FC Martigues | - | Hyères FC | 3:1 | ||||
| 20. Round | 05/03/2022 | Hyères FC | - | GFA Rumilly Vallières | 1:0 | ||||
| 22. Round | 19/03/2022 | Hyères FC | - | Étoile FC | 2:1 | |
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| 23. Round | 26/03/2022 | GOAL FC | - | Hyères FC | 3:3 | ||||
| 25. Round | 16/04/2022 | Jura Sud | - | Hyères FC | 1:0 | ||||
| 27. Round | 29/04/2022 | Marignane Gignac FC | - | Hyères FC | 0:0 | ||||
| 29. Round | 21/05/2022 | RC Grasse | - | Hyères FC | 4:2 | ||||
| 30. Round | 28/05/2022 | Hyères FC | - | Louhans-Cuiseaux | 2:0 |
France