1. Round | 18/07/2021 | River Plate | - | Colón de Santa Fe | 1:2 | ||||
8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | ||||
11. Round | 16/09/2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
12. Round | 20/09/2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
17. Round | 22/10/2021 | Talleres de Córdoba | - | River Plate | 0:2 | ||||
18. Round | 25/10/2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
19. Round | 31/10/2021 | Estudiantes | - | River Plate | 1:1 | ||||
20. Round | 07/11/2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
21. Round | 22/11/2021 | Platense | - | River Plate | 0:1 | ||||
22. Round | 26/11/2021 | River Plate | - | Racing Club | 4:0 | ||||
23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 | ||||
24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 | ||||
25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |