| 4. Round | 28/01/2022 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:3 |  |
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| 5. Round | 31/01/2022 | CF América [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 6. Round | 07/02/2022 | Club Necaxa [Women] | - | Atlas Guadalajara [Women] | 1:1 | |
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| 7. Round | 13/02/2022 | FC Juárez [Women] | - | Club Necaxa [Women] | 2:3 | ||||
| 8. Round | 01/03/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:0 | ||||
| 9. Round | 05/03/2022 | Mazatlán FC [Women] | - | Club Necaxa [Women] | 2:1 | ||||
| 10. Round | 15/03/2022 | CF Monterrey [Women] | - | Club Necaxa [Women] | 5:2 | ||||
| 11. Round | 17/03/2022 | Club Necaxa [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
| 12. Round | 20/03/2022 | Gallos Blancos [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 13. Round | 29/03/2022 | Club Tijuana [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 14. Round | 31/03/2022 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 1:2 | ||||
| 15. Round | 17/04/2022 | Puebla FC [Women] | - | Club Necaxa [Women] | 0:1 | ||||
| 16. Round | 22/04/2022 | Club Necaxa [Women] | - | Cruz Azul [Women] | 1:2 | ||||
| 17. Round | 01/05/2022 | CF Pachuca [Women] | - | Club Necaxa [Women] | 1:1 |
Mexico