| 5. Round | 26/06/2022 | Independiente II | - | Patronato de Paraná II | 7:1 | ||||
| 6. Round | 01/07/2022 | Platense II | - | Independiente II | 0:1 | ||||
| 7. Round | 07/07/2022 | Independiente II | - | Racing Club II | 1:0 |  |
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| 8. Round | 14/07/2022 | Rosario Central II | - | Independiente II | 5:1 | |
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| 12. Round | 06/08/2022 | River Plate II | - | Independiente II | 2:1 | ||||
| 13. Round | 10/08/2022 | Independiente II | - | Lanús II | 1:2 | ||||
| 15. Round | 20/08/2022 | Independiente II | - | Godoy Cruz II | 0:2 | ||||
| 16. Round | 26/08/2022 | Vélez Sarsfield II | - | Independiente II | 0:1 | ||||
| 17. Round | 01/09/2022 | Independiente II | - | Gimnasia de La Plata II | 4:3 | |
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| 18. Round | 07/09/2022 | Aldosivi II | - | Independiente II | 0:1 |
Argentina