| 7. Round | 23/08/2021 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 11. Round | 16/09/2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Round | 20/09/2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 15. Round | 09/10/2021 | Banfield | - | River Plate | 0:1 | ||||
| 16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Round | 22/10/2021 | Talleres de Córdoba | - | River Plate | 0:2 | ||||
| 18. Round | 25/10/2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 19. Round | 31/10/2021 | Estudiantes | - | River Plate | 1:1 | ||||
| 20. Round | 07/11/2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
| 21. Round | 22/11/2021 | Platense | - | River Plate | 0:1 | ||||
| 22. Round | 26/11/2021 | River Plate | - | Racing Club | 4:0 |  |
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| 23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 | ||||
| 25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentina