| 1. Round | 11/02/2022 | Newell's Old Boys | - | Defensa y Justicia | 1:0 | ||||
| 2. Round | 17/02/2022 | Defensa y Justicia | - | Racing Club | 2:2 | ||||
| 3. Round | 22/02/2022 | San Lorenzo | - | Defensa y Justicia | 3:4 | ||||
| 4. Round | 25/02/2022 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 | ||||
| 6. Round | 15/03/2022 | Argentinos Juniors | - | Defensa y Justicia | 0:1 |  |
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| 7. Round | 21/03/2022 | Defensa y Justicia | - | Arsenal de Sarandí | 1:1 | ||||
| 8. Round | 02/04/2022 | Defensa y Justicia | - | River Plate | 1:2 | ||||
| 9. Round | 09/04/2022 | Talleres de Córdoba | - | Defensa y Justicia | 1:5 | ||||
| 11. Round | 21/04/2022 | Sarmiento de Junín | - | Defensa y Justicia | 2:1 | ||||
| 12. Round | 25/04/2022 | Defensa y Justicia | - | Platense | 1:1 |
Argentina