| 1. Round | 24/07/2021 | CF Monterrey [U20] | - | Puebla FC [U20] | 4:1 |  |
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| 2. Round | 31/07/2021 | CF Monterrey [U20] | - | Pumas UNAM [U20] | 3:1 | |
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| 3. Round | 06/08/2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | |
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| 4. Round | 14/08/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 1:1 | |
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| 6. Round | 21/08/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:1 | |
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| 8. Round | 11/09/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 9. Round | 19/09/2021 | CF Monterrey [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 11. Round | 22/09/2021 | CF Monterrey [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 10. Round | 26/09/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 4:1 | |
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| 14. Round | 19/10/2021 | Gallos Blancos [U20] | - | CF Monterrey [U20] | 1:1 | ||||
| 15. Round | 23/10/2021 | CF Monterrey [U20] | - | Club Necaxa [U20] | 5:1 | ||||
| 16. Round | 31/10/2021 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 3:1 | |
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| 17. Round | 06/11/2021 | CF América [U20] | - | CF Monterrey [U20] | 2:0 |
Mexico