| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 | ||||
| 3. Round | 21/08/2021 | Louhans-Cuiseaux | - | AS Monaco B | 1:1 | ||||
| 4. Round | 28/08/2021 | AS Monaco B | - | Hyères FC | 0:1 | ||||
| 6. Round | 11/09/2021 | SC Toulon | - | AS Monaco B | 3:0 | ||||
| 21. Round | 12/03/2022 | FC Martigues | - | AS Monaco B | 1:2 | ||||
| 22. Round | 19/03/2022 | AS Monaco B | - | GFA Rumilly Vallières | 2:2 | ||||
| 23. Round | 26/03/2022 | AS Saint-Priest | - | AS Monaco B | 2:1 | ||||
| 24. Round | 09/04/2022 | AS Monaco B | - | Étoile FC | 0:1 | ||||
| 26. Round | 23/04/2022 | AS Monaco B | - | Aubagne FC | 1:1 | ||||
| 28. Round | 14/05/2022 | AS Monaco B | - | Olympique Marseille B | 2:4 |
France