| 2. Round | 23/07/2021 | Atlético Tucumán | - | Huracán | 1:0 | ||||
| 3. Round | 28/07/2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 |  |
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| 10. Round | 04/09/2021 | Atlético Tucumán | - | Arsenal de Sarandí | 0:0 | ||||
| 12. Round | 19/09/2021 | Atlético Tucumán | - | Boca Juniors | 1:2 | ||||
| 13. Round | 25/09/2021 | Banfield | - | Atlético Tucumán | 2:0 | ||||
| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 15. Round | 12/10/2021 | Talleres de Córdoba | - | Atlético Tucumán | 2:0 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán | - | Argentinos Juniors | 4:3 | ||||
| 17. Round | 20/10/2021 | Estudiantes | - | Atlético Tucumán | 1:1 | |
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| 18. Round | 25/10/2021 | Atlético Tucumán | - | Patronato de Paraná | 2:2 | ||||
| 19. Round | 30/10/2021 | Platense | - | Atlético Tucumán | 4:1 | |
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| 22. Round | 24/11/2021 | Atlético Tucumán | - | Defensa y Justicia | 0:4 | ||||
| 23. Round | 29/11/2021 | Unión de Santa Fe | - | Atlético Tucumán | 3:0 | |
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| 24. Round | 03/12/2021 | Colón de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |  |
Argentina