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| 1st(1st leg) | Arsenal de Sarandí | - | Banfield | 1:1 (1:0) | ||
| 2nd (2nd leg) | Banfield | - | Arsenal de Sarandí | 3:4 (2:3) | ||
| 1st(1st leg): 10/08/2004 | 2nd (2nd leg): 02/09/2004 | Winner: Arsenal de Sarandí | ||||
| 1st(1st leg) | Cerro Porteño | - | Libertad | 1:1 (0:1) | ||
| 2nd (2nd leg) | Libertad | - | Cerro Porteño | 0:2 (0:1) | ||
| 1st(1st leg): 11/08/2004 | 2nd (2nd leg): 24/08/2004 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | LDU Quito | - | Aucas | 1:0 (1:0) | ||
| 2nd (2nd leg) | Aucas | - | LDU Quito | 1:1 (0:1) | ||
| 1st(1st leg): 11/08/2004 | 2nd (2nd leg): 14/09/2004 | Winner: LDU Quito | ||||
| 1st(1st leg) | Club Aurora | - | Bolívar | 1:2 (0:0) | ||
| 2nd (2nd leg) | Bolívar | - | Club Aurora | 3:1 (0:0) | ||
| 1st(1st leg): 12/08/2004 | 2nd (2nd leg): 19/08/2004 | Winner: Bolívar | ||||
| 1st(1st leg) | Coronel Bolognesi | - | Alianza Atlético | 1:0 (0:0) | ||
| 2nd (2nd leg) | Alianza Atlético | - | Coronel Bolognesi | 4:1 (1:1) | ||
| 1st(1st leg): 17/08/2004 | 2nd (2nd leg): 14/09/2004 | Winner: Alianza Atlético | ||||
| 1st(1st leg) | Quilmes | - | San Lorenzo | 0:2 (0:1) | ||
| 2nd (2nd leg) | San Lorenzo | - | Quilmes | 0:0 (0:0) | ||
| 1st(1st leg): 18/08/2004 | 2nd (2nd leg): 02/09/2004 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Millonarios | - | Atlético Junior | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Millonarios | 2:0 (1:0) | ||
| 1st(1st leg): 19/08/2004 | 2nd (2nd leg): 09/09/2004 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Carabobo FC | - | Cienciano | 1:2 (1:1) | ||
| 2nd (2nd leg) | Cienciano | - | Carabobo FC | 6:1 (1:0) | ||
| 1st(1st leg): 24/08/2004 | 2nd (2nd leg): 31/08/2004 | Winner: Cienciano | ||||
| 1st(1st leg) | Universidad de Concepción | - | Santiago Wanderers | 2:1 (0:0) | ||
| 2nd (2nd leg) | Santiago Wanderers | - | Universidad de Concepción | 0:1 (0:0) | ||
| 1st(1st leg): 31/08/2004 | 2nd (2nd leg): 11/09/2004 | Winner: Universidad de Concepción | ||||
| 1st(1st leg) | Danubio | - | Peñarol | 1:2 (0:2) | ||
| 2nd (2nd leg) | Peñarol | - | Danubio | 1:1 (1:1) | ||
| 1st(1st leg): 09/09/2004 | 2nd (2nd leg): 21/09/2004 | Winner: Peñarol | ||||
| 1st(1st leg) | Internacional | - | Grêmio Porto Alegre | 2:0 (1:0) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Internacional | 2:1 (0:1) | ||
| 1st(1st leg): 15/09/2004 | 2nd (2nd leg): 22/09/2004 | Winner: Internacional | ||||
| 1st(1st leg) | São Caetano - SP | - | São Paulo FC | 1:1 (1:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | São Caetano - SP | 4:1 (1:1, 1:1, 1:1) pso | ||
| 1st(1st leg): 15/09/2004 | 2nd (2nd leg): 22/09/2004 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Santos FC | - | Flamengo RJ | 0:0 (0:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Santos FC | 4:5 (2:1, 2:2, 2:2) pso | ||
| 1st(1st leg): 15/09/2004 | 2nd (2nd leg): 22/09/2004 | Winner: Santos FC | ||||
| 1st(1st leg) | Goiás - GO | - | Cruzeiro | 2:2 (1:1) | ||
| 2nd (2nd leg) | Cruzeiro | - | Goiás - GO | 3:2 (2:1) | ||
| 1st(1st leg): 16/09/2004 | 2nd (2nd leg): 22/09/2004 | Winner: Cruzeiro | ||||
