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| 1st(1st leg) | FK Mladá Boleslav | - | Viktoria Plzeň | 2:1 (2:0) | ||
| 2nd (2nd leg) | Viktoria Plzeň | - | FK Mladá Boleslav | 1:2 (1:0) | ||
| 1st(1st leg): 12/04/2011 16:00 | 2nd (2nd leg): 20/04/2011 19:00 | Winner: FK Mladá Boleslav | ||||
| 1st(1st leg) | Sigma Olomouc | - | FK Baumit Jablonec | 2:0 (0:0) | ||
| 2nd (2nd leg) | FK Baumit Jablonec | - | Sigma Olomouc | 2:1 (1:0) | ||
| 1st(1st leg): 13/04/2011 15:30 | 2nd (2nd leg): 27/04/2011 16:00 | Winner: Sigma Olomouc | ||||
| 1st(1st leg) | Zbrojovka Brno | - | Hanácká Slávia Kroměříž | 1:2 (0:1) | ||
| 2nd (2nd leg) | Hanácká Slávia Kroměříž | - | Zbrojovka Brno | 1:0 (0:0) | ||
| 1st(1st leg): 13/04/2011 17:00 | 2nd (2nd leg): 20/04/2011 16:00 | Winner: Hanácká Slávia Kroměříž | ||||
| 1st(1st leg) | FK Teplice | - | Slavia Praha | 2:1 (1:0) | ||
| 2nd (2nd leg) | Slavia Praha | - | FK Teplice | 1:0 (0:0) | ||
| 1st(1st leg): 14/04/2011 17:00 | 2nd (2nd leg): 21/04/2011 17:00 | Winner: Slavia Praha | ||||
