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| 1st(1st leg) | UD SS Reyes | - | CD Tenerife | 2:0 (2:0) | ||
| 2nd (2nd leg) | CD Tenerife | - | UD SS Reyes | 4:0 (2:0, 2:0) aet | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: CD Tenerife | ||||
| 1st(1st leg) | CD Badajoz | - | Real Oviedo | 3:1 (3:1) | ||
| 2nd (2nd leg) | Real Oviedo | - | CD Badajoz | 0:1 (0:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: CD Badajoz | ||||
| 1st(1st leg) | Sevilla FC | - | UD Salamanca | 0:0 (0:0) | ||
| 2nd (2nd leg) | UD Salamanca | - | Sevilla FC | 0:2 (0:2) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Sevilla FC | ||||
| 1st(1st leg) | Jerez CF | - | Deportivo La Coruña | 1:3 (0:0) | ||
| 2nd (2nd leg) | Deportivo La Coruña | - | Jerez CF | 3:1 (1:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 10/11/1998 | Winner: Deportivo La Coruña | ||||
| 1st(1st leg) | Málaga CF | - | Real Valladolid | 1:2 (1:1) | ||
| 2nd (2nd leg) | Real Valladolid | - | Málaga CF | 3:2 (0:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Real Valladolid | ||||
| 1st(1st leg) | Talavera CF | - | Villarreal CF | 0:1 (0:1) | ||
| 2nd (2nd leg) | Villarreal CF | - | Talavera CF | 3:0 (1:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Levante UD | - | CF Extremadura | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Extremadura | - | Levante UD | 1:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Levante UD | ||||
| 1st(1st leg) | SD Beasain | - | Benidorm CD | 0:0 | ||
| 2nd (2nd leg) | Benidorm CD | - | SD Beasain | 1:0 | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Benidorm CD | ||||
| 1st(1st leg) | UD Las Palmas | - | CD Alavés | 0:0 (0:0) | ||
| 2nd (2nd leg) | CD Alavés | - | UD Las Palmas | 2:2 (1:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: UD Las Palmas | ||||
| 1st(1st leg) | Sporting Gijón | - | Real Zaragoza | 1:1 (0:1) | ||
| 2nd (2nd leg) | Real Zaragoza | - | Sporting Gijón | 2:2 (1:0) | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Sporting Gijón | ||||
| 1st(1st leg) | UE Lleida | - | CA Osasuna | 1:1 | ||
| 2nd (2nd leg) | CA Osasuna | - | UE Lleida | 2:0 | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: CA Osasuna | ||||
| 1st(1st leg) | CD Numancia | - | Racing Santander | 0:1 (0:0) | ||
| 2nd (2nd leg) | Racing Santander | - | CD Numancia | 1:1 (0:0, 0:1) aet | ||
| 1st(1st leg): 28/10/1998 | 2nd (2nd leg): 11/11/1998 | Winner: Racing Santander | ||||
