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| 12/10/2011 | 11:00 | RC Celta | - | Real Valladolid | 4:1 (1:0) | |
| 15:00 | AD Alcorcón | - | CD Numancia | 2:1 (2:1) | ||
| 17:00 | Orihuela CF | - | Cádiz CF | 1:3 (0:2) | ||
| 17:00 | Andorra CF | - | CD San Roque | 1:3 (0:2) | ||
| 17:00 | CD Mirandés | - | UD Logroñés | 3:1 (2:0) | ||
| 17:00 | Córdoba CF | - | SD Huesca | 3:2 (0:0, 1:1, 1:1) pso | ||
| 18:00 | Albacete | - | CD Alavés | 1:0 (1:0) | ||
| 18:30 | UE Llagostera | - | CE L'Hospitalet | 0:1 (0:1) | ||
| 19:00 | SD Eibar | - | SD Ponferradina | 0:1 (0:1) | ||
| 19:00 | UD Almería | - | Elche CF | 1:0 (0:0) | ||
| 21:00 | Deportivo La Coruña | - | CD Alcoyano | 2:1 (1:0) |
