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| 22/01/2019 | 17:30 | Toulouse FC | - | Stade de Reims | 4:3 (1:0, 3:3, 4:4) pso | |
| 17:30 | AS Nancy Lorraine | - | EA Guingamp | 1:2 (0:1, 1:1) aet | ||
| 17:30 | ASF Andrézieux | - | AS Lyon Duchère | 1:2 (1:0) | ||
| 17:30 | FC Villefranche Beaujolais | - | Vendée Les Herbiers | 2:0 (0:0) | ||
| 20:00 | FC Sète | - | Lille OSC | 0:1 (0:0) | ||
| 20:00 | AS Monaco | - | FC Metz | 1:3 (1:1) | ||
| 23/01/2019 | 17:30 | AS Saint-Étienne | - | Dijon FCO | 3:6 (1:2) | |
| 17:30 | St-Pryvé St-Hilaire | - | Stade Rennais | 0:2 (0:1) | ||
| 17:30 | Bergerac Périgord FC | - | US Orléans | 2:3 (0:0, 2:2) aet | ||
| 17:30 | ES Viry-Chatillon | - | SM Caen | 0:6 (0:3) | ||
| 17:30 | Marignane Gignac FC | - | IC Croix | 3:4 (0:0, 0:0, 0:0) pso | ||
| 20:05 | Paris Saint-Germain | - | RC Strasbourg | 2:0 (1:0) | ||
| 24/01/2019 | 17:00 | SC Bastia | - | Noisy-Le-Grand FC | 2:1 (2:0) | |
| 17:00 | AS Vitré | - | Havre AC | 3:0 (1:0) | ||
| 20:00 | Amiens SC | - | Olympique Lyonnais | 0:2 (0:2) | ||
| 02/02/2019 | 14:00 | Entente SSG | - | FC Nantes | 0:1 (0:0) |
