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| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:4 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| 1st(1st leg): 21/05/2022 03:00 | 2nd (2nd leg): 24/05/2022 02:05 | Winner: Deportivo Guadalajara | ||||
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| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:4 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| 1st(1st leg): 21/05/2022 03:00 | 2nd (2nd leg): 24/05/2022 02:05 | Winner: Deportivo Guadalajara | ||||
