 |
 |
|
| 1st(1st leg) | Atlas Guadalajara | - | UANL Tigres | 0:7 (0:4) | ||
| 2nd (2nd leg) | UANL Tigres | - | Atlas Guadalajara | 2:1 (2:1) | ||
| 1st(1st leg): 05/05/2022 23:00 | 2nd (2nd leg): 09/05/2022 03:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | CF Pachuca | - | CF América | 2:1 (1:1) | ||
| 2nd (2nd leg) | CF América | - | CF Pachuca | 1:2 (0:1) | ||
| 1st(1st leg): 06/05/2022 01:00 | 2nd (2nd leg): 08/05/2022 18:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Pumas UNAM | - | Deportivo Guadalajara | 2:2 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Pumas UNAM | 3:2 (1:2) | ||
| 1st(1st leg): 07/05/2022 00:00 | 2nd (2nd leg): 10/05/2022 01:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Club Tijuana | - | CF Monterrey | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Club Tijuana | 2:1 (2:0) | ||
| 1st(1st leg): 07/05/2022 03:00 | 2nd (2nd leg): 10/05/2022 03:00 | Winner: CF Monterrey | ||||
