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| 20/01/2022 | 19:45 | Hibernian FC | - | Cove Rangers | 1:0 (0:0, 0:0) aet | |
| 21/01/2022 | 19:45 | Rangers FC | - | Stirling Albion FC | 4:0 (2:0) | |
| 22/01/2022 | 12:30 | Auchinleck Talbot | - | Heart of Midlothian | 0:5 (0:2) | |
| 15:00 | Peterhead FC | - | East Kilbride FC | 5:3 (2:1, 2:2, 2:2) pso | ||
| 15:00 | Clydebank FC | - | Annan Athletic | 3:4 (1:1, 2:2) aet | ||
| 15:00 | Banks O’ Dee FC | - | Raith Rovers | 0:3 (0:0) | ||
| 15:00 | Motherwell FC | - | Greenock Morton FC | 2:1 (0:0, 0:0) aet | ||
| 15:00 | Kelty Hearts | - | St. Johnstone FC | 1:0 (0:0, 0:0) aet | ||
| 15:00 | Livingston FC | - | Ross County FC | 1:0 (1:0) | ||
| 15:00 | Dumbarton FC | - | Dundee FC | 0:1 (0:0) | ||
| 15:00 | Aberdeen FC | - | Edinburgh City FC | 3:0 (2:0) | ||
| 15:00 | Ayr United | - | St. Mirren FC | 0:2 (0:2) | ||
| 15:00 | Kilmarnock FC | - | Dundee United | 1:2 (1:1, 1:1) aet | ||
| 15:00 | Partick Thistle | - | Airdrieonians FC | 1:0 (1:0) | ||
| 15:00 | Arbroath FC | - | Darvel FC | 3:0 (1:0) | ||
| 17:30 | Alloa Athletic | - | Celtic FC | 1:2 (0:2) |
