| 1. Round | 19/07/2021 | Independiente | - | Argentinos Juniors | 0:0 | ||||
| 3. Round | 28/07/2021 | Independiente | - | Patronato de Paraná | 2:0 | ||||
| 5. Round | 09/08/2021 | Independiente | - | Racing Club | 1:0 | ||||
| 7. Round | 21/08/2021 | Independiente | - | Defensa y Justicia | 0:0 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 | ||||
| 12. Round | 19/09/2021 | Huracán | - | Independiente | 0:1 | ||||
| 13. Round | 26/09/2021 | Independiente | - | Godoy Cruz | 1:4 | ||||
| 14. Round | 03/10/2021 | Vélez Sarsfield | - | Independiente | 3:3 | ||||
| 15. Round | 11/10/2021 | Independiente | - | Gimnasia de La Plata | 1:1 | ||||
| 16. Round | 17/10/2021 | Aldosivi | - | Independiente | 1:0 | ||||
| 18. Round | 26/10/2021 | Independiente | - | Unión de Santa Fe | 1:0 |  |
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| 19. Round | 31/10/2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 21. Round | 21/11/2021 | Central Córdoba SdE | - | Independiente | 1:0 | ||||
| 22. Round | 25/11/2021 | Independiente | - | Boca Juniors | 1:0 | ||||
| 23. Round | 01/12/2021 | Banfield | - | Independiente | 4:1 | ||||
| 24. Round | 05/12/2021 | Independiente | - | San Lorenzo | 1:1 |
Argentina