| 1. Round | 19/07/2021 | Central Córdoba SdE | - | Banfield | 1:1 | ||||
| 11. Round | 14/09/2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | ||||
| 12. Round | 19/09/2021 | Colón de Santa Fe | - | Central Córdoba SdE | 1:0 | ||||
| 13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Round | 02/10/2021 | Lanús | - | Central Córdoba SdE | 2:1 | ||||
| 16. Round | 15/10/2021 | Godoy Cruz | - | Central Córdoba SdE | 0:0 | ||||
| 17. Round | 20/10/2021 | Central Córdoba SdE | - | Vélez Sarsfield | 1:2 | ||||
| 18. Round | 23/10/2021 | Gimnasia de La Plata | - | Central Córdoba SdE | 2:2 | ||||
| 19. Round | 02/11/2021 | Central Córdoba SdE | - | Aldosivi | 0:0 | ||||
| 20. Round | 07/11/2021 | Sarmiento de Junín | - | Central Córdoba SdE | 1:3 |  |
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| 21. Round | 21/11/2021 | Central Córdoba SdE | - | Independiente | 1:0 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 |
Argentina
Italy