| 1. Round | 19/07/2021 | Central Córdoba SdE | - | Banfield | 1:1 | ||||
| 3. Round | 28/07/2021 | Unión de Santa Fe | - | Banfield | 0:1 | ||||
| 6. Round | 14/08/2021 | Argentinos Juniors | - | Banfield | 2:0 | ||||
| 7. Round | 20/08/2021 | Banfield | - | Estudiantes | 1:1 |  |
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| 8. Round | 24/08/2021 | Patronato de Paraná | - | Banfield | 1:1 | |
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| 9. Round | 28/08/2021 | Banfield | - | Platense | 2:4 | ||||
| 15. Round | 09/10/2021 | Banfield | - | River Plate | 0:1 | ||||
| 16. Round | 16/10/2021 | Lanús | - | Banfield | 1:1 | |
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| 17. Round | 20/10/2021 | Banfield | - | Huracán | 1:4 | ||||
| 18. Round | 24/10/2021 | Godoy Cruz | - | Banfield | 2:1 | ||||
| 19. Round | 30/10/2021 | Banfield | - | Vélez Sarsfield | 2:1 | ||||
| 20. Round | 07/11/2021 | Gimnasia de La Plata | - | Banfield | 0:1 | |
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| 23. Round | 01/12/2021 | Banfield | - | Independiente | 4:1 | ||||
| 24. Round | 07/12/2021 | Newell's Old Boys | - | Banfield | 0:0 | |
Argentina