| 1. Round | 07/01/2021 | Gallos Blancos [Women] | - | Mazatlán FC [Women] | 1:2 | ||||
| 2. Round | 16/01/2021 | Mazatlán FC [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 3. Round | 24/01/2021 | Mazatlán FC [Women] | - | CF América [Women] | 1:1 | ||||
| 7. Round | 14/02/2021 | Atlético San Luis [Women] | - | Mazatlán FC [Women] | 3:0 |  |
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| 12. Round | 18/03/2021 | Cruz Azul [Women] | - | Mazatlán FC [Women] | 3:0 | ||||
| 13. Round | 27/03/2021 | Mazatlán FC [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 14. Round | 05/04/2021 | Deportivo Toluca [Women] | - | Mazatlán FC [Women] | 1:0 | ||||
| 15. Round | 17/04/2021 | Mazatlán FC [Women] | - | CF Pachuca [Women] | 0:2 | ||||
| 16. Round | 27/04/2021 | UANL Tigres [Women] | - | Mazatlán FC [Women] | 2:2 | ||||
| 17. Round | 01/05/2021 | Mazatlán FC [Women] | - | Santos Laguna [Women] | 2:3 |
Mexico