| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 |  |
|||
| 3. Round | 28/07/2021 | Boca Juniors | - | San Lorenzo | 0:2 | ||||
| 4. Round | 02/08/2021 | San Lorenzo | - | Banfield | 1:1 | ||||
| 5. Round | 07/08/2021 | Unión de Santa Fe | - | San Lorenzo | 4:0 | ||||
| 6. Round | 16/08/2021 | Talleres de Córdoba | - | San Lorenzo | 2:0 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 |  |
|||
| 16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | |
|||
| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
| 19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | |
|||
| 20. Round | 07/11/2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | ||||
| 23. Round | 30/11/2021 | San Lorenzo | - | Sarmiento de Junín | 1:0 | ||||
| 24. Round | 05/12/2021 | Independiente | - | San Lorenzo | 1:1 |
Argentina