| 1. Round | 08/01/2021 | Club Necaxa [Women] | - | Cruz Azul [Women] | 0:2 | ||||
| 2. Round | 19/01/2021 | CF Monterrey [Women] | - | Club Necaxa [Women] | 5:0 | ||||
| 4. Round | 29/01/2021 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:1 | ||||
| 11. Round | 15/03/2021 | Club Necaxa [Women] | - | Gallos Blancos [Women] | 1:0 | ||||
| 12. Round | 22/03/2021 | Deportivo Toluca [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 13. Round | 26/03/2021 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 14. Round | 02/04/2021 | Club Necaxa [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 15. Round | 17/04/2021 | Atlas Guadalajara [Women] | - | Club Necaxa [Women] | 3:1 | ||||
| 16. Round | 23/04/2021 | Club Necaxa [Women] | - | CF Pachuca [Women] | 1:0 | ||||
| 17. Round | 04/05/2021 | Club Tijuana [Women] | - | Club Necaxa [Women] | 3:0 |
Mexico