| 2. Round | 16/01/2021 | Atlas Guadalajara [Women] | - | UANL Tigres [Women] | 2:1 | ||||
| 3. Round | 26/01/2021 | UANL Tigres [Women] | - | Puebla FC [Women] | 2:1 | ||||
| 4. Round | 02/02/2021 | Santos Laguna [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 5. Round | 05/02/2021 | Atlético San Luis [Women] | - | UANL Tigres [Women] | 0:0 | ||||
| 7. Round | 15/02/2021 | Club León [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 9. Round | 06/03/2021 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 10. Round | 11/03/2021 | UANL Tigres [Women] | - | Gallos Blancos [Women] | 1:0 | ||||
| 12. Round | 23/03/2021 | UANL Tigres [Women] | - | FC Juárez [Women] | 3:0 |  |
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| 14. Round | 06/04/2021 | UANL Tigres [Women] | - | Cruz Azul [Women] | 3:0 |  |
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| 15. Round | 20/04/2021 | Club Tijuana [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 16. Round | 27/04/2021 | UANL Tigres [Women] | - | Mazatlán FC [Women] | 2:2 |
Mexico