| 2. Round | 17/01/2021 | Puebla FC [Women] | - | Pumas UNAM [Women] | 0:3 | ||||
| 3. Round | 21/01/2021 | Pumas UNAM [Women] | - | CF Monterrey [Women] | 3:0 | ||||
| 6. Round | 08/02/2021 | Cruz Azul [Women] | - | Pumas UNAM [Women] | 0:2 | ||||
| 8. Round | 25/02/2021 | CF América [Women] | - | Pumas UNAM [Women] | 3:1 | ||||
| 12. Round | 20/03/2021 | Pumas UNAM [Women] | - | Club León [Women] | 2:0 | ||||
| 13. Round | 27/03/2021 | Mazatlán FC [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 14. Round | 03/04/2021 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 4:1 | ||||
| 15. Round | 17/04/2021 | Pumas UNAM [Women] | - | Gallos Blancos [Women] | 3:2 | ||||
| 16. Round | 24/04/2021 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 1:1 |
Mexico