| 1. Round | 19/07/2021 | Central Córdoba SdE | - | Banfield | 1:1 | ||||
| 3. Round | 29/07/2021 | Central Córdoba SdE | - | Talleres de Córdoba | 2:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors | - | Central Córdoba SdE | 1:1 | ||||
| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 |  |
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| 11. Round | 14/09/2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | |
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| 13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 16. Round | 15/10/2021 | Godoy Cruz | - | Central Córdoba SdE | 0:0 | ||||
| 17. Round | 20/10/2021 | Central Córdoba SdE | - | Vélez Sarsfield | 1:2 | ||||
| 18. Round | 23/10/2021 | Gimnasia de La Plata | - | Central Córdoba SdE | 2:2 | ||||
| 20. Round | 07/11/2021 | Sarmiento de Junín | - | Central Córdoba SdE | 1:3 | ||||
| 21. Round | 21/11/2021 | Central Córdoba SdE | - | Independiente | 1:0 | ||||
| 24. Round | 03/12/2021 | Central Córdoba SdE | - | Unión de Santa Fe | 2:0 | ||||
| 25. Round | 12/12/2021 | Boca Juniors | - | Central Córdoba SdE | 8:1 |
Argentina