| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 8. Round | 26/08/2021 | Estudiantes | - | San Lorenzo | 2:0 |  |
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| 9. Round | 30/08/2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
| 10. Round | 04/09/2021 | Platense | - | San Lorenzo | 1:1 | |
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| 11. Round | 13/09/2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 |  |
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| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | |
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| 15. Round | 11/10/2021 | San Lorenzo | - | Colón de Santa Fe | 1:2 | ||||
| 16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | |
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| 17. Round | 20/10/2021 | San Lorenzo | - | Lanús | 1:3 | |
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| 19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 20. Round | 07/11/2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | ||||
| 21. Round | 19/11/2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
| 22. Round | 23/11/2021 | Aldosivi | - | San Lorenzo | 2:0 |  |
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| 24. Round | 05/12/2021 | Independiente | - | San Lorenzo | 1:1 | ||||
| 25. Round | 12/12/2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
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