| 1. Round | 04/06/2022 | River Plate II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Round | 10/06/2022 | Defensa y Justicia II | - | Lanús II | 1:0 |  |
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| 3. Round | 14/06/2022 | Huracán II | - | Defensa y Justicia II | 3:0 | ||||
| 4. Round | 20/06/2022 | Defensa y Justicia II | - | Godoy Cruz II | 1:0 | ||||
| 5. Round | 27/06/2022 | Vélez Sarsfield II | - | Defensa y Justicia II | 1:2 | ||||
| 6. Round | 01/07/2022 | Defensa y Justicia II | - | Gimnasia de La Plata II | 1:2 | ||||
| 7. Round | 07/07/2022 | Aldosivi II | - | Defensa y Justicia II | 0:1 | ||||
| 8. Round | 13/07/2022 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:1 | ||||
| 9. Round | 19/07/2022 | Independiente II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 28/08/2022 | Defensa y Justicia II | - | Banfield II | 1:2 | ||||
| 17. Round | 01/09/2022 | San Lorenzo II | - | Defensa y Justicia II | 1:0 | ||||
| 18. Round | 08/09/2022 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:1 | ||||
| 19. Round | 14/09/2022 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 20. Round | 17/09/2022 | Defensa y Justicia II | - | Estudiantes II | 0:0 | ||||
| 23. Round | 03/10/2022 | Racing Club II | - | Defensa y Justicia II | 1:1 |
Argentina