| 1. Round | 07/11/2021 | Pierikos Katerini | - | Xanthi FC | 1:1 | ||||
| 3. Round | 21/11/2021 | Xanthi FC | - | Thesprotos | 1:0 |  |
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| 4. Round | 24/11/2021 | AO Kavala | - | Xanthi FC | 0:6 | ||||
| 5. Round | 28/11/2021 | Xanthi FC | - | Almopos Arideas | 2:0 | ||||
| 6. Round | 05/12/2021 | Niki Volou FC | - | Xanthi FC | 0:1 | ||||
| 7. Round | 11/12/2021 | Xanthi FC | - | Olympiakos Volou | 2:0 | ||||
| 8. Round | 15/12/2021 | PAOK Saloniki II | - | Xanthi FC | 0:1 |  |
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| 9. Round | 19/12/2021 | Xanthi FC | - | AO Trikala | 5:0 | ||||
| 15. Round | 22/01/2022 | Xanthi FC | - | Veria FC | 0:3 | ||||
| 11. Round | 26/01/2022 | Xanthi FC | - | Apollon Lárissa | 0:0 | ||||
| 17. Round | 06/02/2022 | Xanthi FC | - | Anagennisi Karditsa | 5:2 | ||||
| 13. Round | 09/02/2022 | Xanthi FC | - | Panserraikos | 0:0 | ||||
| 18. Round | 13/02/2022 | Xanthi FC | - | Pierikos Katerini | 3:0 | ||||
| 20. Round | 20/02/2022 | Thesprotos | - | Xanthi FC | 0:0 | ||||
| 22. Round | 06/03/2022 | Almopos Arideas | - | Xanthi FC | 2:2 | ||||
| 23. Round | 09/03/2022 | Xanthi FC | - | Niki Volou FC | 0:0 |
France
Haiti