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| 01/01/2022 | OGC Nice | - | Paris FC / Olympique Lyon | dnp | ||
| 02/01/2022 | 12:45 | AS Cannes | - | Toulouse FC | 0:1 (0:0) | |
| 12:45 | FC Versailles | - | La Roche VF | 4:0 (4:0) | ||
| 12:45 | Stade Brestois 29 | - | Girondins Bordeaux | 3:0 (1:0) | ||
| 12:45 | FC Nantes | - | AS Vitré | 2:0 (1:0) | ||
| 15:00 | Bergerac Périgord FC | - | US Créteil-Lusitanos | 5:4 (0:0, 0:0) pso | ||
| 15:00 | AS Nancy Lorraine | - | Stade Rennais | 4:3 (0:0, 1:1) pso | ||
| 15:00 | SC Bastia | - | Clermont Foot 63 | 2:0 (1:0) | ||
| 15:00 | Montpellier HSC | - | RC Strasbourg | 1:0 (1:0) | ||
| 17:30 | ESA Linas-Montlhéry | - | Amiens SC | 3:4 (0:0, 3:3) pso | ||
| 17:30 | ES Thaon | - | Stade de Reims | 0:1 (0:0) | ||
| 17:30 | Jura Sud | - | AS Saint-Étienne | 1:4 (0:2) | ||
| 17:30 | US Quevilly-Rouen | - | AS Monaco | 1:3 (1:2) | ||
| 20:00 | US Chauvigny | - | Olympique Marseille | 0:3 (0:2) | ||
| 03/01/2022 | 20:10 | Vannes OC | - | Paris Saint-Germain | 0:4 (0:1) | |
| 04/01/2022 | 20:00 | RC Lens | - | Lille OSC | 4:3 (0:2, 2:2) pso |
