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| 28/01/2022 | 20:00 | FC Nantes | - | Stade Brest | 2:0 (1:0) | |
| 29/01/2022 | 15:15 | Toulouse FC | - | FC Versailles | 0:1 (0:0) | |
| 15:15 | AS Nancy | - | Amiens SC | 0:2 (0:2) | ||
| 17:30 | Stade Reims | - | SC Bastia | 3:5 (1:0, 1:1) pso | ||
| 20:00 | Olympique Marseille | - | Montpellier HSC | 5:4 (0:0, 1:1) pso | ||
| 30/01/2022 | 17:30 | Bergerac Foot | - | AS Saint-Étienne | 1:0 (0:0) | |
| 20:00 | RC Lens | - | AS Monaco | 2:4 (1:3) | ||
| 31/01/2022 | 20:15 | Paris Saint-Germain | - | OGC Nice | 5:6 (0:0, 0:0) pso |
