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| 1st(1st leg) | Sivas Belediyespor | - | Trabzonspor | 2:2 (1:1) | ||
| 2nd (2nd leg) | Trabzonspor | - | Sivas Belediyespor | 5:0 (3:0) | ||
| 1st(1st leg): 04/12/2018 10:00 | 2nd (2nd leg): 19/12/2018 17:30 | Winner: Trabzonspor | ||||
| 1st(1st leg) | Nazilli Belediyespor | - | Göztepe | 0:3 (0:1) | ||
| 2nd (2nd leg) | Göztepe | - | Nazilli Belediyespor | 2:1 (1:1) | ||
| 1st(1st leg): 04/12/2018 11:45 | 2nd (2nd leg): 18/12/2018 14:00 | Winner: Göztepe | ||||
| 1st(1st leg) | Gençlerbirliği | - | Hatayspor | 2:1 (0:0) | ||
| 2nd (2nd leg) | Hatayspor | - | Gençlerbirliği | 2:0 (1:0) | ||
| 1st(1st leg): 04/12/2018 11:45 | 2nd (2nd leg): 20/12/2018 10:00 | Winner: Hatayspor | ||||
| 1st(1st leg) | Antalyaspor | - | Darıca Gençlerbirliği | 2:2 (1:1) | ||
| 2nd (2nd leg) | Darıca Gençlerbirliği | - | Antalyaspor | 0:1 (0:0) | ||
| 1st(1st leg): 04/12/2018 13:45 | 2nd (2nd leg): 20/12/2018 10:45 | Winner: Antalyaspor | ||||
| 1st(1st leg) | Alanyaspor | - | Kahramanmaraşspor | 7:2 (1:1) | ||
| 2nd (2nd leg) | Kahramanmaraşspor | - | Alanyaspor | 2:1 (0:0) | ||
| 1st(1st leg): 04/12/2018 15:30 | 2nd (2nd leg): 19/12/2018 12:00 | Winner: Alanyaspor | ||||
| 1st(1st leg) | Çaykur Rizespor | - | Balıkesirspor | 0:2 (0:2) | ||
| 2nd (2nd leg) | Balıkesirspor | - | Çaykur Rizespor | 1:1 (0:0) | ||
| 1st(1st leg): 04/12/2018 17:30 | 2nd (2nd leg): 18/12/2018 12:00 | Winner: Balıkesirspor | ||||
| 1st(1st leg) | Keçiörengücü | - | Galatasaray | 1:2 (0:1) | ||
| 2nd (2nd leg) | Galatasaray | - | Keçiörengücü | 1:1 (0:0) | ||
| 1st(1st leg): 05/12/2018 10:00 | 2nd (2nd leg): 18/12/2018 17:30 | Winner: Galatasaray | ||||
| 1st(1st leg) | Ümraniyespor | - | 1461 Trabzon | 4:1 (1:0) | ||
| 2nd (2nd leg) | 1461 Trabzon | - | Ümraniyespor | 3:1 (0:1) | ||
| 1st(1st leg): 05/12/2018 11:45 | 2nd (2nd leg): 18/12/2018 10:00 | Winner: Ümraniyespor | ||||
| 1st(1st leg) | Boluspor | - | Van BBSK | 5:1 (0:0) | ||
| 2nd (2nd leg) | Van BBSK | - | Boluspor | 2:2 (1:1) | ||
| 1st(1st leg): 05/12/2018 14:00 | 2nd (2nd leg): 19/12/2018 10:00 | Winner: Boluspor | ||||
| 1st(1st leg) | Altay Izmir | - | Kayserispor | 1:2 (0:0) | ||
| 2nd (2nd leg) | Kayserispor | - | Altay Izmir | 4:1 (2:0) | ||
| 1st(1st leg): 05/12/2018 15:30 | 2nd (2nd leg): 19/12/2018 15:30 | Winner: Kayserispor | ||||
| 1st(1st leg) | Adana Demirspor | - | İstanbul Başakşehir | 1:1 (0:0) | ||
| 2nd (2nd leg) | İstanbul Başakşehir | - | Adana Demirspor | 2:0 (2:0) | ||
| 1st(1st leg): 05/12/2018 17:30 | 2nd (2nd leg): 18/12/2018 16:00 | Winner: İstanbul Başakşehir | ||||
| 1st(1st leg) | Bodrum Belediyesi | - | MKE Ankaragücü | 4:2 (0:0) | ||
| 2nd (2nd leg) | MKE Ankaragücü | - | Bodrum Belediyesi | 3:2 (1:2) | ||
| 1st(1st leg): 06/12/2018 10:00 | 2nd (2nd leg): 18/12/2018 10:45 | Winner: Bodrum Belediyesi | ||||
| 1st(1st leg) | Fatih Karagümrük SK | - | Akhisar Belediyespor | 1:4 (0:1) | ||
| 2nd (2nd leg) | Akhisar Belediyespor | - | Fatih Karagümrük SK | 2:0 (0:0) | ||
| 1st(1st leg): 06/12/2018 12:00 | 2nd (2nd leg): 20/12/2018 15:00 | Winner: Akhisar Belediyespor | ||||
| 1st(1st leg) | Menemen Belediyespor | - | Kasımpaşa SK | 1:2 (0:0) | ||
| 2nd (2nd leg) | Kasımpaşa SK | - | Menemen Belediyespor | 4:1 (3:0) | ||
| 1st(1st leg): 06/12/2018 14:00 | 2nd (2nd leg): 19/12/2018 14:00 | Winner: Kasımpaşa SK | ||||
| 1st(1st leg) | Yeni Malatyaspor | - | Etimesgut Belediyespor | 2:0 (0:0) | ||
| 2nd (2nd leg) | Etimesgut Belediyespor | - | Yeni Malatyaspor | 0:2 (0:0) | ||
| 1st(1st leg): 06/12/2018 15:30 | 2nd (2nd leg): 19/12/2018 10:45 | Winner: Yeni Malatyaspor | ||||
| 1st(1st leg) | Fenerbahçe | - | Giresunspor | 1:0 (0:0) | ||
| 2nd (2nd leg) | Giresunspor | - | Fenerbahçe | 2:5 (1:1) | ||
| 1st(1st leg): 06/12/2018 17:30 | 2nd (2nd leg): 20/12/2018 17:30 | Winner: Fenerbahçe | ||||
