| 4. Round | 29/01/2021 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 1:1 | ||||
| 9. Round | 06/03/2021 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 10. Round | 11/03/2021 | Santos Laguna [Women] | - | Pumas UNAM [Women] | 2:2 | ||||
| 11. Round | 15/03/2021 | Pumas UNAM [Women] | - | Atlético San Luis [Women] | 0:0 | ||||
| 12. Round | 20/03/2021 | Pumas UNAM [Women] | - | Club León [Women] | 2:0 | ||||
| 13. Round | 27/03/2021 | Mazatlán FC [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 14. Round | 03/04/2021 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 4:1 | ||||
| 15. Round | 17/04/2021 | Pumas UNAM [Women] | - | Gallos Blancos [Women] | 3:2 | ||||
| 16. Round | 24/04/2021 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 17. Round | 03/05/2021 | Deportivo Toluca [Women] | - | Pumas UNAM [Women] | 0:1 |
Mexico