| 1. Round | 11/01/2021 | CF América [Women] | - | Atlas Guadalajara [Women] | 1:2 | ||||
| 2. Round | 16/01/2021 | Atlas Guadalajara [Women] | - | UANL Tigres [Women] | 2:1 | ||||
| 8. Round | 27/02/2021 | Mazatlán FC [Women] | - | Atlas Guadalajara [Women] | 2:2 | ||||
| 9. Round | 06/03/2021 | Atlas Guadalajara [Women] | - | Cruz Azul [Women] | 0:1 | ||||
| 10. Round | 12/03/2021 | FC Juárez [Women] | - | Atlas Guadalajara [Women] | 1:2 | ||||
| 11. Round | 14/03/2021 | Atlas Guadalajara [Women] | - | Deportivo Guadalajara [Women] | 3:3 |  |
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| 12. Round | 19/03/2021 | Gallos Blancos [Women] | - | Atlas Guadalajara [Women] | 0:1 | ||||
| 13. Round | 27/03/2021 | Atlas Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:2 | ||||
| 14. Round | 02/04/2021 | Atlético San Luis [Women] | - | Atlas Guadalajara [Women] | 1:2 | ||||
| 15. Round | 17/04/2021 | Atlas Guadalajara [Women] | - | Club Necaxa [Women] | 3:1 | |
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| 16. Round | 24/04/2021 | Pumas UNAM [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 17. Round | 04/05/2021 | CF Monterrey [Women] | - | Atlas Guadalajara [Women] | 3:1 |
Mexico