1st(1st leg) Unión La Calera - Chapecoense 0:0 (0:0)
2nd (2nd leg) Chapecoense - Unión La Calera 1:1 (0:1)
1st(1st leg): 05/02/2019 23:30 2nd (2nd leg): 20/02/2019 00:30 Winner: Unión La Calera
1st(1st leg) Botafogo - RJ - Defensa y Justicia 1:0 (0:0)
2nd (2nd leg) Defensa y Justicia - Botafogo - RJ 0:3 (0:0)
1st(1st leg): 06/02/2019 23:30 2nd (2nd leg): 21/02/2019 00:30 Winner: Botafogo - RJ
1st(1st leg) Bahia - BA - Liverpool 0:1 (0:0)
2nd (2nd leg) Liverpool - Bahia - BA 0:0 (0:0)
1st(1st leg): 07/02/2019 21:15 2nd (2nd leg): 21/02/2019 22:15 Winner: Liverpool
1st(1st leg) Deportivo Santaní - Once Caldas 1:1 (1:0)
2nd (2nd leg) Once Caldas - Deportivo Santaní 0:2 (0:1)
1st(1st leg): 07/02/2019 23:30 2nd (2nd leg): 22/02/2019 00:30 Winner: Deportivo Santaní
1st(1st leg) River Plate - Santos FC 0:0 (0:0)
2nd (2nd leg) Santos FC - River Plate 1:1 (0:0)
1st(1st leg): 12/02/2019 21:15 2nd (2nd leg): 26/02/2019 22:15 Winner: River Plate
1st(1st leg) Macará - CD Guabirá 2:1 (2:1)
2nd (2nd leg) CD Guabirá - Macará 0:3 (0:0)
1st(1st leg): 12/02/2019 23:30 2nd (2nd leg): 01/03/2019 00:30 Winner: Macará
1st(1st leg) Royal Pari - Monagas 2:1 (2:1)
2nd (2nd leg) Monagas - Royal Pari 2:4 (1:1, 2:1) pso
1st(1st leg): 14/02/2019 21:15 2nd (2nd leg): 27/02/2019 22:15 Winner: Royal Pari
1st(1st leg) Corinthians SP - Racing Club 1:1 (0:1)
2nd (2nd leg) Racing Club - Corinthians SP 4:5 (1:0, 1:1) pso
1st(1st leg): 14/02/2019 23:30 2nd (2nd leg): 28/02/2019 00:30 Winner: Corinthians SP
1st(1st leg) Fluminense RJ - Antofagasta 0:0 (0:0)
2nd (2nd leg) Antofagasta - Fluminense RJ 1:2 (1:1)
1st(1st leg): 27/02/2019 00:30 2nd (2nd leg): 21/03/2019 22:15 Winner: Fluminense RJ
1st(1st leg) Unión Española - Mushuc Runa 1:1 (0:0)
2nd (2nd leg) Mushuc Runa - Unión Española 5:6 (1:1, 1:1) pso
1st(1st leg): 19/03/2019 22:15 2nd (2nd leg): 19/04/2019 01:30 Winner: Unión Española
1st(1st leg) Deportivo Municipal - Colón de Santa Fe 0:3 (0:1)
2nd (2nd leg) Colón de Santa Fe - Deportivo Municipal 2:0 (1:0)
1st(1st leg): 20/03/2019 00:30 2nd (2nd leg): 17/04/2019 01:30 Winner: Colón de Santa Fe
1st(1st leg) Nacional Potosí - Zulia FC 0:1 (0:0)
2nd (2nd leg) Zulia FC - Nacional Potosí 2:0 (0:1, 0:1) pso
1st(1st leg): 20/03/2019 00:30 2nd (2nd leg): 16/04/2019 21:00 Winner: Zulia FC
1st(1st leg) Independiente CG - La Equidad 0:0 (0:0)
2nd (2nd leg) La Equidad - Independiente CG 4:3 (0:0, 0:0) pso
1st(1st leg): 21/03/2019 00:30 2nd (2nd leg): 17/04/2019 01:30 Winner: La Equidad
1st(1st leg) Unión de Santa Fe - Independiente del Valle 2:0 (1:0)
2nd (2nd leg) Independiente del Valle - Unión de Santa Fe 4:2 (1:0, 2:0) pso
1st(1st leg): 21/03/2019 00:30 2nd (2nd leg): 18/04/2019 01:30 Winner: Independiente del Valle
1st(1st leg) Montevideo Wanderers - Sport Huancayo 2:0 (2:0)
2nd (2nd leg) Sport Huancayo - Montevideo Wanderers 1:1 (0:0)
1st(1st leg): 21/03/2019 22:15 2nd (2nd leg): 19/04/2019 01:30 Winner: Montevideo Wanderers
1st(1st leg) Águilas Doradas - Oriente Petrolero 1:1 (0:1)
2nd (2nd leg) Oriente Petrolero - Águilas Doradas 0:3 (1:1, 1:1) pso
1st(1st leg): 22/03/2019 00:30 2nd (2nd leg): 18/04/2019 01:30 Winner: Águilas Doradas
1st(1st leg) Mineros de Guayana - Sol de América 1:0 (0:0)
2nd (2nd leg) Sol de América - Mineros de Guayana 4:3 (0:0, 1:0) pso
1st(1st leg): 02/04/2019 21:00 2nd (2nd leg): 01/05/2019 23:15 Winner: Sol de América
1st(1st leg) Universidad Catolica - Colo-Colo 0:1 (0:1)
2nd (2nd leg) Colo-Colo - Universidad Catolica 0:3 (0:1, 0:1) pso
1st(1st leg): 03/04/2019 01:30 2nd (2nd leg): 01/05/2019 01:30 Winner: Universidad Catolica
1st(1st leg) Independiente - Deportivo Binacional 4:1 (2:0)
2nd (2nd leg) Deportivo Binacional - Independiente 1:2 (0:0)
1st(1st leg): 04/04/2019 01:30 2nd (2nd leg): 02/05/2019 01:30 Winner: Independiente
1st(1st leg) Universidad Técnica - CA Cerro 1:1 (1:1)
2nd (2nd leg) CA Cerro - Universidad Técnica 3:1 (2:0)
1st(1st leg): 04/04/2019 01:30 2nd (2nd leg): 30/04/2019 23:15 Winner: CA Cerro
1st(1st leg) Argentinos Juniors - Estudiantes de Mérida 2:0 (1:0)
2nd (2nd leg) Estudiantes de Mérida - Argentinos Juniors 1:0 (1:0)
1st(1st leg): 04/04/2019 23:15 2nd (2nd leg): 08/05/2019 21:00 Winner: Argentinos Juniors
1st(1st leg) Deportivo Cali - Guaraní 1:0 (1:0)
2nd (2nd leg) Guaraní - Deportivo Cali 1:4 (0:0, 1:0) pso
1st(1st leg): 05/04/2019 01:30 2nd (2nd leg): 03/05/2019 01:30 Winner: Deportivo Cali