| 29. Round | 22/01/2022 | Rotherham United | - | Cheltenham Town | 1:0 | ||||
| 17. Round | 01/02/2022 | AFC Wimbledon | - | Cheltenham Town | 2:2 | ||||
| 32. Round | 08/02/2022 | Cheltenham Town | - | Sunderland AFC | 2:1 | ||||
| 33. Round | 12/02/2022 | Cheltenham Town | - | Fleetwood Town | 2:0 | ||||
| 34. Round | 19/02/2022 | Wycombe Wanderers | - | Cheltenham Town | 5:5 | ||||
| 35. Round | 22/02/2022 | Ipswich Town | - | Cheltenham Town | 0:0 | ||||
| 36. Round | 26/02/2022 | Cheltenham Town | - | Crewe Alexandra | 1:2 | ||||
| 37. Round | 05/03/2022 | Cheltenham Town | - | Doncaster Rovers | 4:0 | ||||
| 25. Round | 08/03/2022 | Milton Keynes Dons | - | Cheltenham Town | 3:1 | ||||
| 39. Round | 19/03/2022 | Cheltenham Town | - | AFC Wimbledon | 3:1 | ||||
| 41. Round | 02/04/2022 | Accrington Stanley | - | Cheltenham Town | 4:4 | ||||
| 43. Round | 15/04/2022 | Cheltenham Town | - | Gillingham FC | 2:2 | ||||
| 44. Round | 18/04/2022 | Lincoln City | - | Cheltenham Town | 3:0 |  |
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| 45. Round | 23/04/2022 | Cheltenham Town | - | Bolton Wanderers | 1:2 |  |
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| 46. Round | 30/04/2022 | Cambridge United | - | Cheltenham Town | 2:2 |
England