| 3. Round | 31/08/2024 | Brentford FC | - | Southampton FC | 3:1 | ||||
| 4. Round | 14/09/2024 | Southampton FC | - | Manchester United | 0:3 | ||||
| 5. Round | 21/09/2024 | Southampton FC | - | Ipswich Town | 1:1 |  |
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| 6. Round | 30/09/2024 | AFC Bournemouth | - | Southampton FC | 3:1 | |
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| 9. Round | 26/10/2024 | Manchester City | - | Southampton FC | 1:0 | |
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| 10. Round | 02/11/2024 | Southampton FC | - | Everton FC | 1:0 | ||||
| 11. Round | 09/11/2024 | Wolverhampton Wanderers | - | Southampton FC | 2:0 | ||||
| 12. Round | 24/11/2024 | Southampton FC | - | Liverpool FC | 2:3 | |
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| 18. Round | 26/12/2024 | Southampton FC | - | West Ham United | 0:1 | ||||
| 19. Round | 29/12/2024 | Crystal Palace | - | Southampton FC | 2:1 | ||||
| 20. Round | 04/01/2025 | Southampton FC | - | Brentford FC | 0:5 | ||||
| 23. Round | 25/01/2025 | Southampton FC | - | Newcastle United | 1:3 | ||||
| 24. Round | 01/02/2025 | Ipswich Town | - | Southampton FC | 1:2 | ||||
| 28. Round | 08/03/2025 | Liverpool FC | - | Southampton FC | 3:1 |
England
