| 1. Round | 06/11/2021 | Northampton Town | - | Cambridge United | 2:2 | ||||
| 1. Round | 16/11/2021 | Cambridge United | - | Northampton Town | 3:1 | ||||
| 2. Round | 04/12/2021 | Cambridge United | - | Exeter City | 2:1 |  |
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| 3. Round | 08/01/2022 | Newcastle United | - | Cambridge United | 0:1 | ||||
| 4. Round | 05/02/2022 | Cambridge United | - | Luton Town | 0:3 |  |
England