| 1. Round | 30/07/2022 | Cambridge United | - | Milton Keynes Dons | 1:0 | ||||
| 2. Round | 06/08/2022 | Oxford United | - | Cambridge United | 1:0 | ||||
| 3. Round | 13/08/2022 | Cambridge United | - | Exeter City | 2:1 | ||||
| 4. Round | 16/08/2022 | Portsmouth FC | - | Cambridge United | 4:1 | ||||
| 5. Round | 20/08/2022 | Charlton Athletic | - | Cambridge United | 1:1 | ||||
| 6. Round | 27/08/2022 | Cambridge United | - | Burton Albion | 4:3 | ||||
| 7. Round | 03/09/2022 | Cambridge United | - | Lincoln City | 2:0 | ||||
| 9. Round | 13/09/2022 | Cheltenham Town | - | Cambridge United | 2:1 |  |
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| 10. Round | 17/09/2022 | Cambridge United | - | Barnsley FC | 0:3 | ||||
| 11. Round | 24/09/2022 | Morecambe FC | - | Cambridge United | 1:2 | ||||
| 12. Round | 01/10/2022 | Cambridge United | - | Derby County | 0:2 | ||||
| 8. Round | 04/10/2022 | Ipswich Town | - | Cambridge United | 3:0 | ||||
| 14. Round | 08/10/2022 | Bristol Rovers | - | Cambridge United | 2:1 |
England