| 1. Round | 07/08/2021 | Bolton Wanderers | - | Milton Keynes Dons | 3:3 | ||||
| 3. Round | 17/08/2021 | Milton Keynes Dons | - | Charlton Athletic | 2:1 | ||||
| 4. Round | 21/08/2021 | Ipswich Town | - | Milton Keynes Dons | 2:2 | ||||
| 17. Round | 13/11/2021 | Milton Keynes Dons | - | Cambridge United | 4:1 | ||||
| 18. Round | 20/11/2021 | Milton Keynes Dons | - | Burton Albion | 1:0 | ||||
| 19. Round | 23/11/2021 | Sheffield Wednesday | - | Milton Keynes Dons | 2:1 |  |
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| 21. Round | 08/12/2021 | Milton Keynes Dons | - | Plymouth Argyle | 1:1 | ||||
| 22. Round | 11/12/2021 | Milton Keynes Dons | - | Oxford United | 1:2 | ||||
| 28. Round | 15/01/2022 | Portsmouth FC | - | Milton Keynes Dons | 1:2 |
England