| 1. Round | 24/02/2024 | Columbus Crew | - | Atlanta United FC | 1:0 | ||||
| 2. Round | 02/03/2024 | Minnesota United FC | - | Columbus Crew | 1:1 | ||||
| 3. Round | 10/03/2024 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 4. Round | 16/03/2024 | Columbus Crew | - | New York RB | 3:0 |  |
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| 6. Round | 31/03/2024 | Nashville SC | - | Columbus Crew | 2:2 | ||||
| 7. Round | 07/04/2024 | Columbus Crew | - | D.C. United | 1:1 | |
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| 8. Round | 14/04/2024 | Real Salt Lake | - | Columbus Crew | 0:0 | ||||
| 9. Round | 21/04/2024 | Columbus Crew | - | Portland Timbers | 2:2 | ||||
| 10. Round | 28/04/2024 | Columbus Crew | - | CF Montréal | 0:0 | ||||
| 12. Round | 12/05/2024 | Columbus Crew | - | FC Cincinnati | 1:2 | ||||
| 13. Round | 16/05/2024 | CF Montréal | - | Columbus Crew | 1:3 | ||||
| 14. Round | 19/05/2024 | Chicago Fire | - | Columbus Crew | 1:3 | ||||
| 15. Round | 26/05/2024 | Orlando City | - | Columbus Crew | 0:2 | ||||
| 18. Round | 15/06/2024 | New York City FC | - | Columbus Crew | 2:3 | ||||
| 19. Round | 20/06/2024 | Inter Miami CF | - | Columbus Crew | 2:1 | ||||
| 20. Round | 23/06/2024 | Columbus Crew | - | Sporting Kansas City | 4:0 |
USA
Canada